Lipophilic Statins Inhibit CD44 Fragmentation In Chondrocytes
نویسندگان
چکیده
منابع مشابه
Simvastatin inhibits CD44 fragmentation in chondrocytes.
In human osteoarthritic chondrocytes, the hyaluronan receptor CD44 undergoes proteolytic cleavage at the cell surface. CD44 cleavage is thought to require transit of CD44 into cholesterol-rich lipid rafts. The purpose of this study was to investigate whether statins exert a protective effect on articular chondrocytes due to diminution of cholesterol. Three model systems of chondrocytes were exa...
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OBJECTIVE A recent report identified the small molecule kartogenin as a chondrogenic and chondroprotective agent. Since changes in hyaluronan metabolism occur during cartilage degeneration in osteoarthritis, we began studies to determine whether there was a connection between extracellular hyaluronan, CD44-hyaluronan interactions and the effects of kartogenin on articular chondrocytes. METHOD...
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INTRODUCTION: Hyaluronan (HA) functions to retain aggrecan within cartilage. The HA/proteoglycan-rich cell-associated matrix is anchored to chondrocytes by HA binding to CD44, the principal cell surface receptor for HA. CD44 mediates the endocytosis of HA that results in HA catabolism intracellularly via the action of lysosomal hyaluronidases. The hyaluronidases are represented by a family of β...
متن کاملAlterations in CD44 isoforms and HAS expression in human articular chondrocytes during the de- and re-differentiation processes.
The purpose of this study was to investigate the expression of different CD44 and hyaluronan synthase isoforms in cartilage, their alterations during the chondrocyte dedifferentiation process in monolayer culture and during the redifferentiation process on 3D scaffolds. Chondrocytes isolated from human articular cartilage were cultured as a monolayer for up to 36 days and were seeded on two dif...
متن کاملDifferential effect of molecular size HA in mouse chondrocytes stimulated with PMA.
BACKGROUND Hyaluronan (HA) fragments elicit the expression of inflammatory mediators through a mechanism involving the CD44 receptor. This study investigated the effects of HA at different molecular weights on PMA-induced inflammation in mouse chondrocytes. METHODS mRNA and related protein levels were measured for CD44, PKCdelta, PKCepsilon, TNF-alpha, IL-1beta, MMP-13, and iNOS in chondrocyt...
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تاریخ انتشار 2014